Manufacturer: ParthPack: 250mg 6 pillsChemical Substance: Azithromycin
Azithromycin is a bacteriostatic broad–spectrum antibiotic from the group of macrolides–azalides. Has a wide spectrum of antimicrobial action. The mechanism of action of azithromycin is associated with the suppression of protein synthesis of the microbial cell. Linking to the 508 subunit of the ribosomes, inhibits peptidranslokase at the stage of translation and suppresses protein synthesis, slowing the growth and multiplication of bacteria. In high concentrations has a bactericidal effect.
It has activity against a number of gram–positive, gram–negative, anaerobes, intracellular and other microorganisms.
Microorganisms can initially be resistant to the action of an antibiotic or can acquire resistance to it.
AK TO ACCEPT AZITROMYCIN?
Azithromycin can be in the form of capsules and in tablets 250 milligrams (mg). There are also 600 mg tablets. This preparation is also available in powder form and in liquid form. In order to combat most infections, the dosage for adults is 500 mg on the first day, then 250 mg daily for a further 4 days.
Dosage for the prevention of MAC infection is 1200 mg or 1250 mg once a week.
WHAT ARE THE SIDE EFFECTS?
In general, the side effects of azithromycin affect the digestive system. This is diarrhea, nausea and pain in the abdomen. Some people become very sensitive to sunlight. Some have headaches, dizziness, or drowsiness, as well as hearing problems. These side effects occur in very few people who take azithromycin. However, most anti–HIV drugs also cause problems in the digestive system. Azithromycin can enhance these problems.
Some people have an acute allergic reaction to azithromycin. Tell your doctor immediately if you have severe diarrhea, fever, severe spasms or pain in the stomach, swelling in the neck, mouth, hands and feet, or shortness of breath.
Antibiotics kill useful bacteria, which usually live in the digestive system. You can eat yogurts or take acidophilic supplements to restore these bacteria.
Azithromycin, as a prokinetic
Azithromycin, like other macrolides, is an agonist of the motilin receptors and therefore possesses prokinetic effects and, in this capacity, is considered as a means of affecting the motility of the gastrointestinal tract. It has been shown that in patients with GERD with small hernia of the esophageal aperture of the diaphragm (<3 cm), the azithromycin treatment reduces the size of the hernia, increases the period of its stabilization and promotes the movement of the “acid pocket” to a more distal position compared with placebo. At the same time, the intensity of acid reflux was reduced (from 38% to 17%), while the total number of refluxes did not change. In patients with large hernias (≥ 3 cm), these effects were not observed (Bordin DS). Application as a prokinetics with functional dyspepsia is not shown in connection with “non–physiological acceleration of gastric emptying“